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KMID : 0381219740060010041
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Journal of RIMSK
1974 Volume.6 No. 1 p.41 ~ p.48
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Interaction of Hypocapnia and Hypoxia upon Cardiovascular Dynamics
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Abstract
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Acute hypoxia was induced by 6% oxygen in nitrogen with succinyl choline-apnea to allow ventilation at normocapnia (PaCO2 40±2). Hypocapnia was combined with hypoxia in a group of dogs by exposing them to 6% oxygen in 94% nitrogen with ventilation at PaCO2 20±2 by hyperventilation or by dead space removal. All experiments were done after a control period under PaCO2 40±2 without hypoxia. The acid-base status and hemodynamic parameters were continuously determined during 30 minutes of hypoxia. These studies were made in dogs with electromagnetic flow probes chronically implanted around the ascending aorta.
Hypoxia caused a marked decrease in cardiac output in the normocapnic dogs, but cardiac output was not decreased during hypoxia in hypocapnic dogs. Mean arterial blood pressure was also decreased by hypoxia in normocapnic animals and unchanged in hypocapnic dogs. Central venous pressure was greatly increased by prolonged hypoxia in normocapnic dogs, but this was not observed during hyoxia in hypocapnic animals. Cardiac arrest occurred in 4 out of 9 dogs, but this was not observed during hypoxia in any hypocapnic animals.
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